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Asbestos Mesothelioma Cancer Clinical Trials

The US Government keeps an online database, at clinicaltrials.gov, of clinical research studies for Mesothelioma cancer, but doesn't review or approve the safety and science of these trials. The website is maintained by the National Library of Medicine (NLM). The links below go to the clinical trial information on clinicaltrials.gov. Talk with your health care professional about possible risks and benefits before joining any studies.

Study of Iparomlimab and Tuvonralimab Plus Chemotherapy in Malignant Mesothelioma

Wed, 20 Aug 2025 00:00:00 EDT

Conditions: Malignant Mesothelioma; Mesothelioma
Interventions: Drug: iparomlimab and tuvonralimab (Dual PD-1/CTLA-4 blockade) + chemotherapy
Sponsors: National Cancer Center, China; Qilu Pharmaceutical Co., Ltd.; Affiliated Cancer Hospital of Zhengzhou University; Beijing Chest Hospital, Capital Medical University; The Affiliated Hospital of Inner Mongolia Medical University; Shaanxi Provincial Cancer Hospital
Not yet recruiting

Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

Sun, 17 Aug 2025 00:00:00 EDT

Conditions: Mesothelioma; Mesothelioma; Lung; Mesotheliomas Pleural; Mesothelioma Malignant Advanced; Mesothelioma, Malignant
Interventions: Procedure: Partial Pleurectomy
Sponsors: University of Chicago
Not yet recruiting

Prospective Data Collection Initiative on Thoracic Malignancies

Fri, 22 Aug 2025 00:00:00 EDT

Conditions: Lung Cancer; Thoracic Cancer; Lung Cancer, Nonsmall Cell; Adenocarcinoma; Squamous Cell Carcinoma; Large Cell Lung Cancer; Thymus Cancer; Mesothelioma
Interventions: Behavioral: Health-related quality of life and treatment outcome questionnaires; Genetic: (Tumor) tissue and other biomaterials; Procedure: Blood samples
Sponsors: Dutch Society of Physicians for Pulmonology and Tuberculosis
Recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Wed, 27 Aug 2025 00:00:00 EDT

Conditions: Mesothelioma; Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Ovarian Neoplasms; Lung Neoplasms; Thymus Neoplasms; Colonic Neoplasms
Interventions: Device: mesothelin expression testing; Biological: TNhYP217 CAR T Cells; Drug: fludarabine; Drug: cyclophosphamide
Sponsors: National Cancer Institute (NCI)
Recruiting

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

Wed, 27 Aug 2025 00:00:00 EDT

Conditions: Mesothelioma; Malignant Mesothelioma (MM); Early-stage Mesothelioma; Subclinical Mesothelioma; BRCA1-Associated Protein-1 (BAP1) Mutations; Early-stage BAP1-associated Malignancies
Interventions: Drug: alrizomadlin
Sponsors: National Cancer Institute (NCI)
Not yet recruiting

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Wed, 27 Aug 2025 00:00:00 EDT

Conditions: Sarcoma; Small Cell Lung Cancer or Extrapulmonary Neuroendocrine Cancer (EP-NEC); Mesothelioma; Pheochromocytoma/Paraganglioma (PPGL); Pancreatic Ductal Adenocarcinoma; Ovarian Cancer; Hepatocellular Carcinoma; Gastric Cancer; Cholangiocarcinoma; Bladder Cancer
Interventions: Drug: [18F]FAPI-74; Drug: [18F]FDG
Sponsors: National Cancer Institute (NCI)
Recruiting

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

Tue, 26 Aug 2025 00:00:00 EDT

Conditions: Mesothelioma; Malignant Mesothelioma (MM); Early-stage Mesothelioma; Subclinical Mesothelioma; BRCA1-Associated Protein-1 (BAP1) Mutations; Early-stage BAP1-associated Malignancies
Interventions: Drug: Decitabine/cedazuridine
Sponsors: National Cancer Institute (NCI)
Suspended

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

Thu, 21 Aug 2025 00:00:00 EDT

Conditions: Advanced Solid Tumor; NSCLC (Non-small Cell Lung Cancer); Renal Cancer; Mesothelioma; Non-Small Cell Squamous Lung Cancer; Non-small Cell Lung Adenocarcinoma
Interventions: Drug: NXP900
Sponsors: Nuvectis Pharma, Inc.
Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Wed, 20 Aug 2025 00:00:00 EDT

Conditions: High Grade Epithelial Ovarian Cancer; High Grade Serous Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer; Endometrial Cancer; Non-small Cell Lung Cancer; Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (NSCLC); Mesothelioma; Breast Adenocarcinoma; Triple Negative Breast Cancer; Hormone Receptor-positive/Her2 Negative Breast Cancer; Platinum-resistant Ovarian Cancer (PROC); Platinum Sensitive Ovarian Cancer (PSOC); Primary Refractory Ovarian Cancer; Uterine Cancer
Interventions: Drug: Rina-S; Drug: Carboplatin; Drug: Bevacizumab; Drug: Pembrolizumab
Sponsors: Genmab
Recruiting

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Tue, 26 Aug 2025 00:00:00 EDT

Conditions: Carcinoma, Non-Small-Cell Lung; Cutaneous Melanoma; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Nasopharyngeal Carcinoma; Carcinoma, Thymic; Anal Cancer; Mesothelioma; Esophagogastric Cancer; High Microsatellite Instability Colorectal Carcinoma; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Interventions: Drug: KFA115; Drug: pembrolizumab
Sponsors: Novartis Pharmaceuticals
Recruiting